Access. Assistance. Along the Journey.

Exelixis Access Services® (EASE) provides a variety of support to help your patients get started on treatment as soon as possible. EASE can meet the unique needs of your patients and practice at each step along the access journey.

YOUR EASE CASE MANAGER

EASE offers regionally dedicated Case Managers as a single point of contact.
  • Can provide the status of your patient's access journey
  • Offers prompt support with payer coverage, financial assistance, and treatment coordination
  • Provides proactive follow-up

 

CONTACT EASE FOR MORE INFORMATION AND TO ENROLL

Get to know your EASE Case Manager - Your single point of contact at Exelixis Access Services® (EASE).
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CALL: 1-844-900-EASE
(1-844-900-3273)
Monday to Friday, 8:00 AM to 8:00 PM ET
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EASE enrollment

EASE Enrollment Form, including the 15-Day Free Trial Program, EASE Quick Start Program, EASE Co-Pay Program, and the EASE Patient Assistance Program (PAP)

Download the form
consent

15-Day Free Trial Program provides free drug to help patients start treatment quickly

Download the form
enrollment consent

Download the EASE Patient Authorization Form to obtain consent for enrollment in EASE programs

Download the form

HELP PATIENTS START AND STAY ON CABOMETYX® (cabozantinib)

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15-Day Free Trial Program

Provides free drug to help patients start treatment quickly*†

 

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CABOMETYX Quick Start Program*

Provides free drug to eligible patients who experience a payer decision delay of 5 days or more.*†

 

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EASE $0 Co-Pay Program

Eligible commercially insured patients pay $0 per month, for a maximum benefit of $25,000 per year.†

 

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Dose Exchange Program

Provides a free 15-tablet supply in the lower dose to help patients who require a dose reduction.†

 

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EASE Patient Assistance Program (PAP)

Eligible patients who cannot afford their drug costs may receive CABOMETYX free of charge.†

 

copay

EASE $0 Co-Pay Program

Enroll eligible patients
EASE Dose Exchange

EASE Dose Exchange Form to support patients who require a dose reduction

Download the form

SUPPORT FOR COVERAGE DETERMINATION

At your request, EASE can provide support with:

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  • Benefits investigation
  • Prior authorization (PA) assistance
  • Appeals support and follow-up

*Limited to on-label indications. Additional restrictions and eligibility rules apply.
Additional restrictions and eligibility rules apply.

This description of the Exelixis Access Services® (EASE) program is for informational purposes only. Exelixis* makes no representation or guarantee concerning reimbursement or coverage for any service or item. Information provided through the Exelixis Access Services program does not constitute medical or legal advice and is not intended to be a substitute for a consultation with a licensed healthcare provider, legal counsel, or applicable third-party payer(s). Exelixis reserves the right to modify the program at any time without notice.

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) support the use of cabozantinib (CABOMETYX) in the treatment of both aRCC and HCC

National Comprehensive Cancer Network® (NCCN®)

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FIRST- AND SECOND-LINE CLEAR CELL aRCC RECOMMENDATIONS
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Cabozantinib (CABOMETYX) is THE ONLY NCCN “PREFERRED” TKI option for 1L intermediate/poor risk and 2L clear cell aRCC1

As defined by the NCCN Guidelines®, preferred interventions are based on superior efficacy, safety, and evidence; and when appropriate, affordability.

 
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SECOND-LINE HCC RECOMMENDATION
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Cabozantinib (CABOMETYX) is RECOMMENDED AS A CATEGORY 1, SUBSEQUENT-LINE TREATMENT OPTION FOR HCC, following disease progression (Child-Pugh A)2*

*Data reflect use after sorafenib.

Category 1: Based upon high-level evidence, there is uniform NCCN consensus that the intervention is appropriate.

The National Comprehensive Cancer Network makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.

aRCC=advanced renal cell carcinoma; HCC=hepatocellular carcinoma; TKI=tyrosine kinase inhibitor.

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See the trial results that supported the aRCC recommendation

See the clinical data
 

INDICATIONS

CABOMETYX® (cabozantinib) is indicated for the treatment of patients with advanced renal cell carcinoma (RCC).

CABOMETYX® (cabozantinib) is indicated for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.

IMPORTANT SAFETY INFORMATION

WARNINGS AND PRECAUTIONS

Hemorrhage: Severe and fatal hemorrhages occurred with CABOMETYX. The incidence of Grade 3 to 5 hemorrhagic events was 5% in CABOMETYX patients. Discontinue CABOMETYX for Grade 3 or 4 hemorrhage. Do not administer CABOMETYX to patients who have a recent history of hemorrhage, including hemoptysis, hematemesis, or melena.

Perforations and Fistulas: GastrointestinaI (GI) perforations, including fatal cases, occurred in 1% of CABOMETYX patients. Fistulas, including fatal cases, occurred in 1% of CABOMETYX patients. Monitor patients for signs and symptoms of perforations and fistulas, including abscess and sepsis. Discontinue CABOMETYX in patients who experience a fistula that cannot be appropriately managed or a GI perforation.

Thrombotic Events: CABOMETYX increased the risk of thrombotic events. Venous thromboembolism occurred in 7% (including 4% pulmonary embolism) and arterial thromboembolism in 2% of CABOMETYX patients. Fatal thrombotic events occurred in CABOMETYX patients. Discontinue CABOMETYX in patients who develop an acute myocardial infarction or serious arterial or venous thromboembolic event requiring medical intervention.

Hypertension and Hypertensive Crisis: CABOMETYX can cause hypertension, including hypertensive crisis. Hypertension occurred in 36% (17% Grade 3 and <1% Grade 4) of CABOMETYX patients. Do not initiate CABOMETYX in patients with uncontrolled hypertension. Monitor blood pressure regularly during CABOMETYX treatment. Withhold CABOMETYX for hypertension that is not adequately controlled with medical management; when controlled, resume at a reduced dose. Discontinue CABOMETYX for severe hypertension that cannot be controlled with anti-hypertensive therapy or for hypertensive crisis.

Diarrhea: Diarrhea occurred in 63% of CABOMETYX patients. Grade 3 diarrhea occurred in 11% of CABOMETYX patients. Withhold CABOMETYX until improvement to Grade 1 and resume at a reduced dose for intolerable Grade 2 diarrhea, Grade 3 diarrhea that cannot be managed with standard antidiarrheal treatments, or Grade 4 diarrhea.

Palmar-Plantar Erythrodysesthesia (PPE): PPE occurred in 44% of CABOMETYX patients. Grade 3 PPE occurred in 13% of CABOMETYX patients. Withhold CABOMETYX until improvement to Grade 1 and resume at a reduced dose for intolerable Grade 2 PPE or Grade 3 PPE.

Proteinuria: Proteinuria occurred in 7% of CABOMETYX patients. Monitor urine protein regularly during CABOMETYX treatment. Discontinue CABOMETYX in patients who develop nephrotic syndrome.

Osteonecrosis of the Jaw (ONJ): ONJ occurred in <1% of CABOMETYX patients. ONJ can manifest as jaw pain, osteomyelitis, osteitis, bone erosion, tooth or periodontal infection, toothache, gingival ulceration or erosion, persistent jaw pain, or slow healing of the mouth or jaw after dental surgery. Perform an oral examination prior to CABOMETYX initiation and periodically during treatment. Advise patients regarding good oral hygiene practices. Withhold CABOMETYX for at least 28 days prior to scheduled dental surgery or invasive dental procedures. Withhold CABOMETYX for development of ONJ until complete resolution.

Wound Complications: Wound complications were reported with CABOMETYX. Stop CABOMETYX at least 28 days prior to scheduled surgery. Resume CABOMETYX after surgery based on clinical judgment of adequate wound healing. Withhold CABOMETYX in patients with dehiscence or wound healing complications requiring medical intervention.

Reversible Posterior Leukoencephalopathy Syndrome (RPLS): RPLS, a syndrome of subcortical vasogenic edema diagnosed by characteristic finding on MRI, can occur with CABOMETYX. Evaluate for RPLS in patients presenting with seizures, headache, visual disturbances, confusion, or altered mental function. Discontinue CABOMETYX in patients who develop RPLS.

Embryo-Fetal Toxicity: CABOMETYX can cause fetal harm. Advise pregnant women and females of reproductive potential of the potential risk to a fetus. Verify the pregnancy status of females of reproductive potential prior to initiating CABOMETYX and advise them to use effective contraception during treatment and for 4 months after the last dose.

ADVERSE REACTIONS

The most commonly reported (≥25%) adverse reactions are: diarrhea, fatigue, decreased appetite, PPE, nausea, hypertension, and vomiting.

DRUG INTERACTIONS

Strong CYP3A4 Inhibitors: If coadministration with strong CYP3A4 inhibitors cannot be avoided, reduce the CABOMETYX dosage. Avoid grapefruit or grapefruit juice.

Strong CYP3A4 Inducers: If coadministration with strong CYP3A4 inducers cannot be avoided, increase the CABOMETYX dosage. Avoid St. John’s wort.

USE IN SPECIFIC POPULATIONS

Lactation: Advise women not to breastfeed during CABOMETYX treatment and for 4 months after the final dose.

Hepatic Impairment: In patients with moderate hepatic impairment, reduce the CABOMETYX dosage. CABOMETYX is not recommended for use in patients with severe hepatic impairment.

Please see accompanying full Prescribing Information.

Reference: 1. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Kidney Cancer V.2.2019. ©National Comprehensive Cancer Network, Inc. 2018. All rights reserved. Accessed September 26, 2018. To view the most recent and complete version of the guideline, go online to NCCN.org. 2. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Hepatobiliary Cancers V.1.2019. ©National Comprehensive Cancer Network, Inc. 2018. All rights reserved. Accessed December 19, 2018. To view the most recent and complete version of the guideline, go online to NCCN.org.